1/7/2024 0 Comments Sonic charge permut 8![]() Journal of the American Society for Mass Spectrometry 2011, 22 Electrospray Ionization Tandem Mass Spectrometry of Ammonium Cationized Polyethers. Heeren, Irene van Doormalen, Nicolette de Wijs-Rot, Oscar F. Intra- and Inter-Molecular Cross-Linking of Peptide Ions in the Gas Phase: Reagents and Conditions. Chemical Noise Reduction via Mass Spectrometry and Ion/Ion Charge Inversion: Amino Acids. Ion Mobility-Mass Spectrometry Reveals Conformational Changes in Charge Reduced Multiprotein Complexes. ![]() Journal of the American Society for Mass Spectrometry 2012, 23 Solution Versus Gas-Phase Modification of Peptide Cations with NHS-Ester Reagents. Supercharging Protein Complexes from Aqueous Solution Disrupts their Native Conformations. Journal of the American Society for Mass Spectrometry 2014, 25 Effects of Cations on Protein and Peptide Charging in Electrospray Ionization from Aqueous Solutions. Detection of Large Ions in Time-of-Flight Mass Spectrometry: Effects of Ion Mass and Acceleration Voltage on Microchannel Plate Detector Response. The Journal of Physical Chemistry A 2015, 119 IMS–MS and IMS–IMS Investigation of the Structure and Stability of Dimethylamine-Sulfuric Acid Nanoclusters. Hui Ouyang, Siqin He, Carlos Larriba-Andaluz, and Christopher J.Journal of the American Society for Mass Spectrometry 2015, 26 Extensive Charge Reduction and Dissociation of Intact Protein Complexes Following Electron Transfer on a Quadrupole-Ion Mobility-Time-of-Flight MS. Coupling Charge Reduction Mass Spectrometry to Liquid Chromatography for Complex Mixture Analysis. Journal of the American Society for Mass Spectrometry 2017, 28 Conformational Space and Stability of ETD Charge Reduction Products of Ubiquitin. Frederik Lermyte, Mateusz Krzysztof Łącki, Dirk Valkenborg, Anna Gambin, Frank Sobott.Flame Atmospheric Pressure Chemical Ionization Coupled with Negative Electrospray Ionization Mass Spectrometry for Ion Molecule Reactions. Sy-Chyi Cheng, Suhail Muzaffar Bhat, Jentaie Shiea.Journal of the American Society for Mass Spectrometry 2018, 29 Digital Waveform Technology and the Next Generation of Mass Spectrometers. Journal of the American Society for Mass Spectrometry 2019, 30 ![]() Microdroplet Fusion Chemistry for Charge State Reduction of Synthetic Polymers via Bipolar Dual Spray with Anionic Reagents. Recent Developments in Gas-Phase Ion/Ion Reactions for Analytical Mass Spectrometry. Characterization of High Molecular Weight Multi-Arm Functionalized PEG–Maleimide for Protein Conjugation by Charge-Reduction Mass Spectrometry Coupled to Two-Dimensional Liquid Chromatography. Yang, Bifan Chen, Jenny Wang, Kelly Zhang. Discovery of Potent Charge-Reducing Molecules for Native Ion Mobility Mass Spectrometry Studies. McCabe, Samantha Schrecke, Lei Fang, David H. Ion–Ion Charge Reduction Addresses Multiple Challenges Common to Denaturing Intact Mass Analysis. Bailey, Romain Huguet, Christopher Mullen, John E. Approaches to Heterogeneity in Native Mass Spectrometry. ![]() Condensable Vapor Sorption by Low Charge State Protein Ions. Industrial & Engineering Chemistry Research 2022, 61 Machine Learning Assisted Spraying Pattern Recognition for Electrohydrodynamic Atomization System. Jinxin Wang, Tao Dong, Yongpan Cheng, Wei-Cheng Yan.This article is cited by 126 publications. Proton-transfer reactions were found to be responsible for reducing charge on proteins and oligonucleotides in both positive and negative ion mode. The CREMS results obtained exhibit a signal intensity drop-off with increasing oligonucleotide size similar to that observed with matrix-assisted laser desorption/ionization mass spectrometry. The ions are detected using a commercial orthogonal electrospray time-of-flight mass spectrometer, although the neutralization chamber can be adapted to virtually any mass analyzer. The electrospray-generated multiply charged ions undergo charge reduction in a “neutralization chamber” positioned before the entrance nozzle to the mass spectrometer. The charge state of ions produced by electrospray ionization may be reduced in a controlled manner to yield predominantly singly charged ions through reactions with bipolar (i.e., both positively and negatively charged) ions generated using a 210Po α particle source. A new mass spectrometric technique, charge reduction electrospray mass spectrometry (CREMS), allowing the analysis of complex mixtures of biological molecules is described.
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